NEWS
05/12/2024 The SOPhy group welcomes its new PhD student Wenwen YANG. Her thesis will focus on « the reactivity of ynamides ».
26/11/2024 Professor Fabien GAGOSZ visited SOPhy group yesterday, it was a great pleasure to discuss chemistry with him!
05/11/2024 Congratulations to the authors of the publication: « Regio-and Stereoselective Azidation of Activated N-allenamides: an entry to α, β, γ and δ-amido-azides »
Dorian Schutz, Maxime Hourtoule and Laurence Miesch
Org. Chem. Front., 2025, 12, 185 – 191 – DOI: https://doi.org/10.1039/D4QO01802H
03/10/2024 Congratulations to the authors of the publication: « Photocatalyst-free, visible-light-induced regio- and stereoselective synthesis of phosphorylated enamines from N-allenamides via [1,3]-sulfonyl shift at room temperature »
Jia-Dong Guo, Feven Alemu Korsaye, Dorian Schutz, Ilaria Ciofini and Laurence Miesch
Chem. Sci., 2024, (first published on 03 Oct 2024) – DOI: https://doi.org/10.1039/D4SC05190D
01/10/2024 The SOPhy group welcomes its new PhD student Marco MENGHINI. His thesis will focus on «Molecular tools to unravel the mechanism of action of sterols in plants».
27/09/2024 Congratulations to Clément GOMMENGINGER for his PhD defense entitled « Des ynamides pour la synthèse de molécules azotées fluorées inédites » under the supervision of Dr. Laurence Miesch.
08/2024 Congratulations to the authors of the publication: “OsCYP706C2 diverts rice strigolactone biosynthesis to a noncanonical pathway branch”
Changsheng Li, Imran Haider, Jian You Wang, Pierre Quinodoz, Hernando G. Suarez Duran, Lucía Reyes, Méndez Robin Horber, Valentina Fiorilli, Cristina Votta, Luisa Lanfranco, Samara M. Correia de Lemos, Lucile Jouffroy, Baptiste Moegle, Laurence Miesch, Alain De Mesmaeker, Marnix H. Medema, Salim Al-Babili, Lemeng Dong, and Harro J. Bouwmeester
Science Advances, 28 Aug 2024, Vol 10, Issue 35 – DOI: 10.1126/sciadv.adq3942
07/2024 Congratulations to the authors of the publication: “Transition Metal-Free Domino Hydroamination/Isomerization/Transamidation Sequence: An Entry to Trifluorinated γ-Lactams “
Dorian Schutz, Clément Gommenginger, Baptiste Moegle, Maxime Hourtoule, Ludovik Noël-Duchesneau, and Laurence Miesch
J. Org. Chem. 2024 – DOI : https://pubs.acs.org/doi/10.1021/acs.joc.4c00878
21/06/2024 Je suis très fière de vous annoncer que Maxime Hourtoule en plus du prix de la SCF-Alsace, a également obtenu le Prix de Thèse des Amis des Universités de l’Académie de Strasbourg lors de la cérémonie officielle au Palais Universitaire à Strasbourg. Bravo Maxime!!
12/04/2024 Professor Gwilherm EVANO visited SOPhy group, it was a great pleasure to meet this eminent guest!
08/03/2024 Very proud of Maxime Hourtoule who got the Thesis Price from SCF-Alsace and gave a very nice talk !!
29/01/2024 Many thanks to Dr. Amalia I. Poblador Bahamonde, Dr. Olivier Schaad and The Geneva Chemical Society for this kind invitation!
Thanks a lot to Prof. Jerome Lacour and Prof. Michel Rickhaus for the fruitfull discussions!!
04/01/2024 Congratulations to the authors of the publication:
“Metal Free Regio – and Stereoselective Semireduction of CF3-Substituted N-Allenamides “
Clément Gommenginger, Maxime Hourtoule, Marco Menghini and Laurence Miesch
Org. Biomol. Chem., 2024, Advance Article – DOI : https://doi.org/10.1039/D3OB01859H
01/10/2023 The SOPhy group welcomes its new PhD student Dorian Schutz. His thesis will focus on « the reactivity of N-allenamides ».
29/09/2023 Congratulations to Maxime Hourtoule for his PhD defense entitled « Réactivités des N-allènamides activées: Synthèse de briques moléculaires azotées fluorées inédites » under the supervision of Dr. Laurence Miesch.
All the SOPhy group whishes him good luck for his post-doctoral position in Professor Lutz Ackermann’s group!
31/08/2023 Congratulations to the authors of the publication:
« Evolutionary metabolomics of specialized metabolism diversification in the genus Nicotiana highlights N-acylnornicotine innovations »
David Elser, David Pflieger, Claire Vilette, Baptiste Moegle, Laurence Miesch, and Emmanuel Gaquerel
Science Advances, Vol 9, Issue 34, 2023 – DOI: 10.1126/sciadv.ade898
28/08/2023-30/08/2023 Clément enjoyed REGIO 2023 in Freiburg-im-Breisgau and was very happy to present his work!
06/07/2023 Congratulations to the authors of the publication:
« TBAF-promoted carbanion mediated sulfonamide cyclization of CF3-substituted N-allenamides an access to fluorinated gamma-sultams »
Clément Gommenginger, Yongxiang Zheng, Daniele Maccarone, Ilaria Ciofini and Laurence Miesch
Organic Chemistry Frontiers , 2023 (invited paper) – DOI: 10.1039/D3QO00781B
06/03/2023 Congratulations to the authors of the publication:
« Silver-Catalyzed Domino Reaction of CF3Substituted N-Allenamides with Primary Amines for the Construction of 2-Amido-5-fluoropyrroles »
Maxime Hourtoule and Laurence Miesch
Org. Lett., 2023 – DOI : https://doi.org/10.1021/acs.orglett.3c00401
13/02/2023 Professor Mark Lautens visited SOPhy group, it was a great pleasure to meet this eminent guest!
09/12/2022 Congratulations to Baptiste Moegle for his PhD defense entitled « Des énamides pour la synthèse de nouvelles molécules azotées » under the supervision of Dr. Laurence Miesch.
All the SOPhy group whishes him good luck !
08/11/2022 Congratulations to the authors of the publication:
« Construction of C-N and C-O bonds based on N-allenamide functionalization »
Maxime Hourtoule and Laurence Miesch
Org. Biomol. Chem., 2022 -DOI : https://doi.org/10.1039/D2OB01768G
02/11/2022 The SOPhy group welcomes his new Post-doctoral student Jia-Dong GUO. His work will focus on « the reactivity of ynamides ».
02/11/2022 Maxime presented a poster during DCO-Symposium in Paris.
06/07/2022
We celebrated the retirement of Philippe Geoffroy!
We wish him a very nice and well-deserved retirement!
20/06/2022 Congratulations to the authors of the publication:
« Triton B-Promoted Regioselective Intramolecular Addition of Enolates to Tethered Ynamides for the Construction of 8-Membered O-Heterocycles »
Santanu Ghosh, Yongxiang Zheng, Daniele Maccarone, Feven Alemu Korsaye, Ilaria Ciofini, and Laurence Miesch
Org. Chem. Front., 2022 – DOI : 10.1039/D2QO00873D
13-14/06/2022
Professor Gary Molander visited SOPhy group , it was a great pleasure to host this eminent guest!
19/05/2022 Congratulations to the authors of the publication:
« Regio- and Stereoselective Addition to gem-Difluorinated Ene–Ynamides: Access to Stereodefined Fluorinated Dienes »
Maxime Hourtoule and Laurence Miesch
Organic Letters, Articles ASAP (Letter), Publication Date (Web):May 19, 2022 – DOI: 10.1021/acs.orglett.2c01593
12/04/2022 Congratulations to the authors of the publication:
« Synthesis of Non-natural Aza-Iridoids via Ynamides and Molecular Networking-Based Tracing of Their In Planta Bioconversion »
Baptiste Moegle, Maxime Hourtoule, Clément Gommenginger, Asmaa Belabbes, Claire Villette, David Elser, Emmanuel Gaquerel, Nicolas Navrot, and Laurence Miesch
Org. Chem. First published: 12 May 2022 – DOI: https://doi.org/10.1021/acs.joc.2c00445
28/03/2022 Congratulations to the authors of the publication:
« One-Pot anti-Michael Regio- and Stereoselective Hydroamination of Activated N-Allenamides »
Maxime Hourtoule, Yongxiang Zheng, Anna Perfetto, Davide Luise, Ilaria Ciofini, and Laurence Miesch
The Journal of Organic Chemistry, Publication Date (Web): March 28,2022 – DOI: https://doi.org/10.1021/acs.joc.2c00302
07/03/2022
The SOPhy team welcomes Dorian SCHUTZ and Marc GROSS for their M1 internship
09/02/2022
the PhD students of the SOPhy team organized an AMT about « New tools to explore chemical space » online on February, 9th 2022 with the following speakers:
Dr. C. Teskey « Selective cobalt catalysis with light »
Prof. J. Winne « Heterocyclic tools to reshape molecules »
Prof. G. A. Molander « Single electron processes enabling organic synthesis »
It was a great success!!
11/2021 Congratulations to the authors of the publication:
« Copper-Catalyzed Synthesis of Terminal vs. Fluorine-Substituted N- Allenamides via Addition of Diazo Compounds to Terminal Ynamides »
Yongxiang Zheng, Baptiste Moegle, Santanu Ghosh, Anna Perfetto, Davide Luise, Ilaria Ciofini and Laurence Miesch
Chemistry A European Journal, first published: 26 November 2021 – DOI : https://doi.org/10.1002/chem.202103598
01/10/ 2021 THe SOPhy group welcomes its new PhD student Clément Gommenginger. His thesis will focus on « keto-ynamides for the synthesis of polyfunctionnalized systems ».
28/09/2020 Congratulations to Yongxiang Zheng for his PhD defense entitled « Des énamides et des ynamides pour la synthèse d’hétérocycles fonctionnalisés » under the supervision of Dr. Laurence Miesch.
All the SOPhy group whishes him good luck for his post-doctoral position in Professor Gary Molander group!
06/2021 Congratulations to the authors of the publication:
« Direct Synthesis of CF2HSubstituted 2Amidofurans via Copper-Catalyzed Addition of Difluorinated Diazoacetone to Ynamides »
Yongxiang Zheng, Anna Perfetto, Davide Luise, Ilaria Ciofini, Laurence Miesch
Organic Letters, 2021 – DOI : https://doi.org/10.1021/acs.orglett.1c01876
01/03/2021 The SoPhy group welcomes his new Post-doctoral student Santanu Ghosh. His work will focus on « the reactivity of ynamides ».
27/01/2021 The SOPhy group welcomes its new Master 2 Student Clément Gommenginger.
11/2020 Congratulations to the authors of the publication:
« Innate promiscuity of the CYP706 family of P450 enzymes provides a suitable context for the evolution of dinitroaniline resistance in weed »
Fatemeh Abdollahi, Mohammad Taghi Alebrahim, Chheng Ngov, Etienne Lallemand , Younxiang Zheng, Claire Villette, Julie Zumsteg, François André, Nicolas Navrot, Danièle, Werck‐Reichhart, Laurence Miesch, New Phytologist, 2021 – DOI : 10.1111/nph.17126
01/10/2020 The SOPhy group welcomes its new PhD student Maxime Hourtoule . His thesis will focus on » Keto-ynamides for the synthesis of polyfunctionnalized systems »
16/09/2020 Congratulations to Fatemeh Abdollahi for her PhD defense entitled « Investigations on the role of cytochrome P450 enzymes in the evolution of herbicide resistance » under the supervision of Dr. Laurence Miesch, Dr. Danièle Werck, Dr Nicolas Navrot and Dr. Mohammad Alebrahim. All The SOPhy group wishes her all the best.
08/2020 Congratulations to the authors of the publication:
« Tertiary Enamide-Promoted Diastereoselective Domino: N-Acyliminium Ion Trapping and Nazarov Cyclization »
Yongxiang Zheng, Lucile Andna, Olivia Bistri, and Laurence Miesch, Org. Lett. 2020 – DOI : 10.1021/acs.orglett.0c02251
06/2020 Congratulations to Lucile Andna for her thesis prize (Prix de la Commission de la recherche de l’Université de Strasbourg).
05/2020 Congratulations to the authors of the publication:
« Tertiary Enamides as Versatile and Valuable Substrates to Reach Chemical Diversity » (invited review by professor Paul Knochel)
F. Beltran and L. Miesch, Synthesis 2020 – DOI: 10.1055/s-0040-1707403
12/03/2020 The SOPhy team welcomes Fanny Buisson and Clément Gommenginger for their M1 internship
28/02/2020 Professor Frank Glorius visited SOPhy Lab!
01/2020 The SOPhy team welcomes Maxime Hourtoule for his M2 internship
11/2019 Professor Léon Ghosez visited SOPhy Lab !
10/2019 Congratulations to Lucile Andna for her post doctoral position at Prof. Dr. Johan Winne’s lab at Ghent University
10/2019 Congratulations to the authors of the publication:
« Surfactant Micelles Enable Metal-Free Spirocyclization of Keto-Ynamides and Access to Aza-Spiro Scaffolds in Aqueous Media »
F. Beltran, A. V. Vela-Gonzalez, T. Knaub, M. Schmutz, M. P. Krafft, L. Miesch, Eur. J. Org. Chem. 2019 – DOI: 10.1002/ejoc.201901441
10/2019 Congratulations to the authors of the publication:
« A Promiscuous CYP706A3 Reduces Terpene Volatile Emission from Arabidopsis Flowers, with Impacts on Florivores and Floral Microbiome »
B. Boachon, Y. Burdloff, J.X. Ruan, R. Rojo, R. R. Junker, B. Vincent, F. Nicolè, F. Bringel, A. Lesot, L. Henry, J.E. Bassard, S. Mathieu, L. Allouche, I. Kaplan, N. Dudareva, S. Vuilleumier, L. Miesch, F. André, N. Navrot, X.-Y. Chen and D. Werck-Reichhart, Plant Cell, 2019 – DOI: 10.1105/tpc.19.00320
10/2019 The SOPhy team welcomes its new PhD student Baptiste MOEGLE. His thesis will focus on « keto-ynamides for the synthesis of new aza-cyclic systems »
10/2019 The SOPhy team welcomes Quentin BUCK Licence professionnelle Chimie de Synthèse
27/09/2019 Congratulations Lucile Andna for her PhD defense entitled « Synthèses et réactivités d’ynesulfonamides et d’ènesulfonamides tertiaires : vers la synthèse d’hétérocycles azotés » performed under the supervision of Dr. Laurence Miesch .
All the SOPhy group wishes her a good continuation!
06/2019 Congratulations to Frédéric Beltran for his FRC thesis prize.
06/2019 Professor Gaquerel of IBMP and his master 1 students came to extract Eugenol from cloves by steam distillation.
06/2019 Congratulations to the authors of the publication:
« Characterization of Jasmonoyl-Isoleucine (JA-Ile) hormonal catabolic pathways in rice upon wounding and salt stress »
M. Hazman, M. Sühnel, S. Schäfer, J. Zumsteg, A. Lesot, F. Beltran, V. Marquis, L. Herrgott, L. Miesch, M. Riemann and T. Heitz, Rice 2019 – DOI: 0.1186s12284-019-0303-0
05/2019 Congratulations to the authors of the publication:
« Metal-Free Synthesis of Activated Ynesulfonamides and Teritary Enesulfonamides »
L. Andna and L. Miesch, Org. Biomol. Chem. 2019, 17, 5688 – 5692 – DOI: 10.1039/C9OB00947G
03/2019 Congratulations to Frédéric Beltran for his post doctoral position at Prof. Dr. Christopher Teskey’s lab Aachen !
02/2019 Congratulations to the authors of the publication:
« Tertiary Enamide-Triggered SEAr: Domino Allylation and Enamine-Type Addition », F. Beltran, L. Miesch, Org. Lett. 2019, 21, 1569-1573 – DOI : https://doi.org/10.1021/acs.orglett.8b03987
02/2019 The SOPhy team welcomes Maxime Hourtoule for his M1 internship
02/2019 Congratulations to the authors of the publication:
« Diastereo-/Enantioselective Diels-Alder Synthesis of 14b-Hydroxysteroid Scaffolds: A Combined Experimental and DFT Study » Clovis Peter, Philippe Geoffroy, Takatsugu Murata, Takayuki Tonoi, Isamu Shiina and Michel Miesch., Heterocycles, 2019, DOI : 10.3987/COM-18-S(F)99
02/2019 Congratulations to the authors of the publication:
« Spirocyclization of Keto-Ynesulfonamides Promoted by Quaternary Ammonium Salts » Frédéric Beltran, Lucile Andna and Laurence Miesch, Org. Chem. Front. 2019, 6, 373-376, DOI : 10.1039/C8QO00937F
23/11/2018 Congratulations to Lucile Andna the winner of the ED prize for 2018 for her oral presentation.
13/11/2018 Hokkaido University students made a short visit to SOPhy.
02/10/2018 Congratulations to Clovis Peter for his position as Project Manager Junior at NovAlix, Illkirch!.
02/10/2018 The SOPhy team welcomes its new PhD student Yongxiang Zheng ! His thesis will focus on « Keto-ynamides for the synthesis of innovative active ingredients ».
02/10/2018 Congratulations to Dr. Frédéric BELTRAN for his PhD defense entitled « Spirocyclization of keto-sulfonylynamides: toward the synthesis of functionalized azacycles » performed under the supervision of the Dr Laurence Miesch. And all SOPhy team wish him a good continuation!
31/08/2018 Professor Min-Hua Xu (Shangai Institute of Materia Medica) recently made a short visit to SOPhy.
12/07/2018 54th International Conference on Medicinal Chemistry (RICT 2018) – Frédéric Beltran and Lucile Andna having a drink after so much effort.
05/06/2018 LCOS becomes SOPhy! LCOS group’s director Michel Miesch gives way to Laurence Miesch, new director of the SOPhy group.
24/05/2018 We congratulate Michel Miesch (CNRS Research director, LCOS director) for his CNRS Medal of Honor on the occasion of his retirement.
23/05/2018 Congratulations to the authors of the publication:
« Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles », Lucile Andna, Laurence Miesch – DOI: 10.1021/acs.orglett.8b01407
31/01/2018 Congratulations to the authors of the publication:
« Intramolecular Morita-Baylis-Hillman reaction as a strategy for the construction of tricyclic sesquiterpene cores » , Clovis Peter, Philippe Geoffroy, Michel Miesch – DOI: 10.1039/C7OB03124F