NEWS
12/04/2024 Professor Gwilherm EVANO visited SOPhy group, it was a great pleasure to meet this eminent guest!
08/03/2024 Very proud of Maxime Hourtoule who got the Thesis Price from SCF-Alsace and gave a very nice talk !!
29/01/2024 Many thanks to Dr. Amalia I. Poblador Bahamonde, Dr. Olivier Schaad and The Geneva Chemical Society for this kind invitation!
Thanks a lot to Prof. Jerome Lacour and Prof. Michel Rickhaus for the fruitfull discussions!!
04/01/2024 Congratulations to the authors of the publication:
“Metal Free Regio – and Stereoselective Semireduction of CF3-Substituted N-Allenamides “
Clément Gommenginger, Maxime Hourtoule, Marco Menghini and Laurence Miesch
Org. Biomol. Chem., 2024, Advance Article – DOI : https://doi.org/10.1039/D3OB01859H
01/10/2023 The SOPhy group welcomes its new PhD student Dorian Schutz. His thesis will focus on « the reactivity of N-allenamides ».
29/09/2023 Congratulations to Maxime Hourtoule for his PhD defense entitled « Réactivités des N-allènamides activées: Synthèse de briques moléculaires azotées fluorées inédites » under the supervision of Dr. Laurence Miesch.
All the SOPhy group whishes him good luck for his post-doctoral position in Professor Lutz Ackermann’s group!
31/08/2023 Congratulations to the authors of the publication:
« Evolutionary metabolomics of specialized metabolism diversification in the genus Nicotiana highlights N-acylnornicotine innovations »
David Elser, David Pflieger, Claire Vilette, Baptiste Moegle, Laurence Miesch, and Emmanuel Gaquerel
Science Advances, Vol 9, Issue 34, 2023 – DOI: 10.1126/sciadv.ade898
28/08/2023-30/08/2023 Clément enjoyed REGIO 2023 in Freiburg-im-Breisgau and was very happy to present his work!
06/07/2023 Congratulations to the authors of the publication:
« TBAF-promoted carbanion mediated sulfonamide cyclization of CF3-substituted N-allenamides an access to fluorinated gamma-sultams »
Clément Gommenginger, Yongxiang Zheng, Daniele Maccarone, Ilaria Ciofini and Laurence Miesch
Organic Chemistry Frontiers , 2023 (invited paper) – DOI: 10.1039/D3QO00781B
06/03/2023 Congratulations to the authors of the publication:
« Silver-Catalyzed Domino Reaction of CF3Substituted N-Allenamides with Primary Amines for the Construction of 2-Amido-5-fluoropyrroles »
Maxime Hourtoule and Laurence Miesch
Org. Lett., 2023 – DOI : https://doi.org/10.1021/acs.orglett.3c00401
13/02/2023 Professor Mark Lautens visited SOPhy group, it was a great pleasure to meet this eminent guest!
09/12/2022 Congratulations to Baptiste Moegle for his PhD defense entitled « Des énamides pour la synthèse de nouvelles molécules azotées » under the supervision of Dr. Laurence Miesch.
All the SOPhy group whishes him good luck !
08/11/2022 Congratulations to the authors of the publication:
« Construction of C-N and C-O bonds based on N-allenamide functionalization »
Maxime Hourtoule and Laurence Miesch
Org. Biomol. Chem., 2022 -DOI : https://doi.org/10.1039/D2OB01768G
02/11/2022 The SOPhy group welcomes his new Post-doctoral student Jia-Dong GUO. His work will focus on « the reactivity of ynamides ».
02/11/2022 Maxime presented a poster during DCO-Symposium in Paris.
06/07/2022
We celebrated the retirement of Philippe Geoffroy!
We wish him a very nice and well-deserved retirement!
20/06/2022 Congratulations to the authors of the publication:
« Triton B-Promoted Regioselective Intramolecular Addition of Enolates to Tethered Ynamides for the Construction of 8-Membered O-Heterocycles »
Santanu Ghosh, Yongxiang Zheng, Daniele Maccarone, Feven Alemu Korsaye, Ilaria Ciofini, and Laurence Miesch
Org. Chem. Front., 2022 – DOI : 10.1039/D2QO00873D
13-14/06/2022
Professor Gary Molander visited SOPhy group , it was a great pleasure to host this eminent guest!
19/05/2022 Congratulations to the authors of the publication:
« Regio- and Stereoselective Addition to gem-Difluorinated Ene–Ynamides: Access to Stereodefined Fluorinated Dienes »
Maxime Hourtoule and Laurence Miesch
Organic Letters, Articles ASAP (Letter), Publication Date (Web):May 19, 2022 – DOI: 10.1021/acs.orglett.2c01593
12/04/2022 Congratulations to the authors of the publication:
« Synthesis of Non-natural Aza-Iridoids via Ynamides and Molecular Networking-Based Tracing of Their In Planta Bioconversion »
Baptiste Moegle, Maxime Hourtoule, Clément Gommenginger, Asmaa Belabbes, Claire Villette, David Elser, Emmanuel Gaquerel, Nicolas Navrot, and Laurence Miesch
Org. Chem. First published: 12 May 2022 – DOI: https://doi.org/10.1021/acs.joc.2c00445
28/03/2022 Congratulations to the authors of the publication:
« One-Pot anti-Michael Regio- and Stereoselective Hydroamination of Activated N-Allenamides »
Maxime Hourtoule, Yongxiang Zheng, Anna Perfetto, Davide Luise, Ilaria Ciofini, and Laurence Miesch
The Journal of Organic Chemistry, Publication Date (Web): March 28,2022 – DOI: https://doi.org/10.1021/acs.joc.2c00302
07/03/2022
The SOPhy team welcomes Dorian SCHUTZ and Marc GROSS for their M1 internship
09/02/2022
the PhD students of the SOPhy team organized an AMT about « New tools to explore chemical space » online on February, 9th 2022 with the following speakers:
Dr. C. Teskey « Selective cobalt catalysis with light »
Prof. J. Winne « Heterocyclic tools to reshape molecules »
Prof. G. A. Molander « Single electron processes enabling organic synthesis »
It was a great success!!
11/2021 Congratulations to the authors of the publication:
« Copper-Catalyzed Synthesis of Terminal vs. Fluorine-Substituted N- Allenamides via Addition of Diazo Compounds to Terminal Ynamides »
Yongxiang Zheng, Baptiste Moegle, Santanu Ghosh, Anna Perfetto, Davide Luise, Ilaria Ciofini and Laurence Miesch
Chemistry A European Journal, first published: 26 November 2021 – DOI : https://doi.org/10.1002/chem.202103598
01/10/ 2021 THe SOPhy group welcomes its new PhD student Clément Gommenginger. His thesis will focus on « keto-ynamides for the synthesis of polyfunctionnalized systems ».
28/09/2020 Congratulations to Yongxiang Zheng for his PhD defense entitled « Des énamides et des ynamides pour la synthèse d’hétérocycles fonctionnalisés » under the supervision of Dr. Laurence Miesch.
All the SOPhy group whishes him good luck for his post-doctoral position in Professor Gary Molander group!
06/2021 Congratulations to the authors of the publication:
« Direct Synthesis of CF2HSubstituted 2Amidofurans via Copper-Catalyzed Addition of Difluorinated Diazoacetone to Ynamides »
Yongxiang Zheng, Anna Perfetto, Davide Luise, Ilaria Ciofini, Laurence Miesch
Organic Letters, 2021 – DOI : https://doi.org/10.1021/acs.orglett.1c01876
01/03/2021 The SoPhy group welcomes his new Post-doctoral student Santanu Ghosh. His work will focus on « the reactivity of ynamides ».
27/01/2021 The SOPhy group welcomes its new Master 2 Student Clément Gommenginger.
11/2020 Congratulations to the authors of the publication:
« Innate promiscuity of the CYP706 family of P450 enzymes provides a suitable context for the evolution of dinitroaniline resistance in weed »
Fatemeh Abdollahi, Mohammad Taghi Alebrahim, Chheng Ngov, Etienne Lallemand , Younxiang Zheng, Claire Villette, Julie Zumsteg, François André, Nicolas Navrot, Danièle, Werck‐Reichhart, Laurence Miesch, New Phytologist, 2021 – DOI : 10.1111/nph.17126
01/10/2020 The SOPhy group welcomes its new PhD student Maxime Hourtoule . His thesis will focus on » Keto-ynamides for the synthesis of polyfunctionnalized systems »
16/09/2020 Congratulations to Fatemeh Abdollahi for her PhD defense entitled « Investigations on the role of cytochrome P450 enzymes in the evolution of herbicide resistance » under the supervision of Dr. Laurence Miesch, Dr. Danièle Werck, Dr Nicolas Navrot and Dr. Mohammad Alebrahim. All The SOPhy group wishes her all the best.
08/2020 Congratulations to the authors of the publication:
« Tertiary Enamide-Promoted Diastereoselective Domino: N-Acyliminium Ion Trapping and Nazarov Cyclization »
Yongxiang Zheng, Lucile Andna, Olivia Bistri, and Laurence Miesch, Org. Lett. 2020 – DOI : 10.1021/acs.orglett.0c02251
06/2020 Congratulations to Lucile Andna for her thesis prize (Prix de la Commission de la recherche de l’Université de Strasbourg).
05/2020 Congratulations to the authors of the publication:
« Tertiary Enamides as Versatile and Valuable Substrates to Reach Chemical Diversity » (invited review by professor Paul Knochel)
F. Beltran and L. Miesch, Synthesis 2020 – DOI: 10.1055/s-0040-1707403
12/03/2020 The SOPhy team welcomes Fanny Buisson and Clément Gommenginger for their M1 internship
28/02/2020 Professor Frank Glorius visited SOPhy Lab!
01/2020 The SOPhy team welcomes Maxime Hourtoule for his M2 internship
11/2019 Professor Léon Ghosez visited SOPhy Lab !
10/2019 Congratulations to Lucile Andna for her post doctoral position at Prof. Dr. Johan Winne’s lab at Ghent University
10/2019 Congratulations to the authors of the publication:
« Surfactant Micelles Enable Metal-Free Spirocyclization of Keto-Ynamides and Access to Aza-Spiro Scaffolds in Aqueous Media »
F. Beltran, A. V. Vela-Gonzalez, T. Knaub, M. Schmutz, M. P. Krafft, L. Miesch, Eur. J. Org. Chem. 2019 – DOI: 10.1002/ejoc.201901441
10/2019 Congratulations to the authors of the publication:
« A Promiscuous CYP706A3 Reduces Terpene Volatile Emission from Arabidopsis Flowers, with Impacts on Florivores and Floral Microbiome »
B. Boachon, Y. Burdloff, J.X. Ruan, R. Rojo, R. R. Junker, B. Vincent, F. Nicolè, F. Bringel, A. Lesot, L. Henry, J.E. Bassard, S. Mathieu, L. Allouche, I. Kaplan, N. Dudareva, S. Vuilleumier, L. Miesch, F. André, N. Navrot, X.-Y. Chen and D. Werck-Reichhart, Plant Cell, 2019 – DOI: 10.1105/tpc.19.00320
10/2019 The SOPhy team welcomes its new PhD student Baptiste MOEGLE. His thesis will focus on « keto-ynamides for the synthesis of new aza-cyclic systems »
10/2019 The SOPhy team welcomes Quentin BUCK Licence professionnelle Chimie de Synthèse
27/09/2019 Congratulations Lucile Andna for her PhD defense entitled « Synthèses et réactivités d’ynesulfonamides et d’ènesulfonamides tertiaires : vers la synthèse d’hétérocycles azotés » performed under the supervision of Dr. Laurence Miesch .
All the SOPhy group wishes her a good continuation!
06/2019 Congratulations to Frédéric Beltran for his FRC thesis prize.
06/2019 Professor Gaquerel of IBMP and his master 1 students came to extract Eugenol from cloves by steam distillation.
06/2019 Congratulations to the authors of the publication:
« Characterization of Jasmonoyl-Isoleucine (JA-Ile) hormonal catabolic pathways in rice upon wounding and salt stress »
M. Hazman, M. Sühnel, S. Schäfer, J. Zumsteg, A. Lesot, F. Beltran, V. Marquis, L. Herrgott, L. Miesch, M. Riemann and T. Heitz, Rice 2019 – DOI: 0.1186s12284-019-0303-0
05/2019 Congratulations to the authors of the publication:
« Metal-Free Synthesis of Activated Ynesulfonamides and Teritary Enesulfonamides »
L. Andna and L. Miesch, Org. Biomol. Chem. 2019, 17, 5688 – 5692 – DOI: 10.1039/C9OB00947G
03/2019 Congratulations to Frédéric Beltran for his post doctoral position at Prof. Dr. Christopher Teskey’s lab Aachen !
02/2019 Congratulations to the authors of the publication:
« Tertiary Enamide-Triggered SEAr: Domino Allylation and Enamine-Type Addition », F. Beltran, L. Miesch, Org. Lett. 2019, 21, 1569-1573 – DOI : https://doi.org/10.1021/acs.orglett.8b03987
02/2019 The SOPhy team welcomes Maxime Hourtoule for his M1 internship
02/2019 Congratulations to the authors of the publication:
« Diastereo-/Enantioselective Diels-Alder Synthesis of 14b-Hydroxysteroid Scaffolds: A Combined Experimental and DFT Study » Clovis Peter, Philippe Geoffroy, Takatsugu Murata, Takayuki Tonoi, Isamu Shiina and Michel Miesch., Heterocycles, 2019, DOI : 10.3987/COM-18-S(F)99
02/2019 Congratulations to the authors of the publication:
« Spirocyclization of Keto-Ynesulfonamides Promoted by Quaternary Ammonium Salts » Frédéric Beltran, Lucile Andna and Laurence Miesch, Org. Chem. Front. 2019, 6, 373-376, DOI : 10.1039/C8QO00937F
23/11/2018 Congratulations to Lucile Andna the winner of the ED prize for 2018 for her oral presentation.
13/11/2018 Hokkaido University students made a short visit to SOPhy.
02/10/2018 Congratulations to Clovis Peter for his position as Project Manager Junior at NovAlix, Illkirch!.
02/10/2018 The SOPhy team welcomes its new PhD student Yongxiang Zheng ! His thesis will focus on « Keto-ynamides for the synthesis of innovative active ingredients ».
02/10/2018 Congratulations to Dr. Frédéric BELTRAN for his PhD defense entitled « Spirocyclization of keto-sulfonylynamides: toward the synthesis of functionalized azacycles » performed under the supervision of the Dr Laurence Miesch. And all SOPhy team wish him a good continuation!
31/08/2018 Professor Min-Hua Xu (Shangai Institute of Materia Medica) recently made a short visit to SOPhy.
12/07/2018 54th International Conference on Medicinal Chemistry (RICT 2018) – Frédéric Beltran and Lucile Andna having a drink after so much effort.
05/06/2018 LCOS becomes SOPhy! LCOS group’s director Michel Miesch gives way to Laurence Miesch, new director of the SOPhy group.
24/05/2018 We congratulate Michel Miesch (CNRS Research director, LCOS director) for his CNRS Medal of Honor on the occasion of his retirement.
23/05/2018 Congratulations to the authors of the publication:
« Trapping of N-Acyliminium Ions with Enamides: An Approach to Medium-Sized Diaza-Heterocycles », Lucile Andna, Laurence Miesch – DOI: 10.1021/acs.orglett.8b01407
31/01/2018 Congratulations to the authors of the publication:
« Intramolecular Morita-Baylis-Hillman reaction as a strategy for the construction of tricyclic sesquiterpene cores » , Clovis Peter, Philippe Geoffroy, Michel Miesch – DOI: 10.1039/C7OB03124F